Core faculty research interests include: nondestructive evaluation, robotics and medical imaging; nanotechnology and thin films, surface science, electronic and magnetic materials science; physical and chemical properties and characterization of polymers; laser spectroscopy; solid state nuclear magnetic resonance; neurophysiology; computational neuroscience, and cell biology.

Applied Science research takes place both on and off campus. Facilities include the Intergrated Science Center (ISC 3), the Beowulf-like SciClone parallel computing system, the solid state NMR spectroscopy laboratory, the NASA-Langley Research Center (NASA-LaRC) and The Thomas Jefferson National Accelerator Facility (Jefferson Lab).