Areas of Specialization
Oxidative damage to proteins, and its role in neurodegeneration and aging
My research focuses on oxidative damage to proteins and its role in neurodegeneration and aging. Oxidative damage plays a role in many diseases including Alzheimer's and Parkinson's. Currently, we are studying the interactions of native and oxidized tubulin with other proteins and with small molecule redox regulators including nitric oxide and glutathione. All projects in the lab use the techniques of protein biochemistry including: column chromatography for protein purification, SDS-PAGE, Western blotting, labeling of proteins with fluorescent molecules, reverse phase HPLC, and UV/Visible spectroscopy.