Brent Scott

Assistant Professor

Office: Adair Hall 115A
Email: bscott@wm.edu
Research Web Page: : {{https://myolab.org/, Myolab}}

Area of Specialization

Molecular Biophysics

Background

Brent Scott, Assistant Professor of Health Sciences, earned his Ph.D. in Kinesiology from UMass Amherst and completed a postdoc in Biochemistry and Molecular Biophysics at WashU School of Medicine. Professor Scott’s research uses a molecular biophysics approach to understand the role of muscle sarcomere proteins in various diseases and treatments. His teaching assignments will include HHP 101 – Introduction to the Human Body as well as HHP 330 – Nutrition in Human Performance.

Education and Experience

Post-Doctorial Fellow, Biochemistry and Molecular Biophysics, Washington University School of Medicine, 2025
Ph.D., Kinesiology, University of Massachusetts Amherst, 2022
M.S., Kinesiology, University of Massachusette Amherst, 2019
B.S., Exercise Science, Belmont University, 2016

Courses Taught

HHP 101 - Introduction to the Human Body
HHP 330 - Nutrition in Human Performance

Select Peer-Reviewed Publications

Shuyue Liu, Chris Marang, Mike Woodward, Venus Joumaa, Tim Leonard, Brett Scott, Edward Debold, Walter Herzog, and Sam Walcott. Modeling thick filament activation suggests a molecular basis for force depression. Biophysical Journal 2024; 123, 555-571.
Brent Scott and Michael J. Greenberg. Multiscale biophysical models of cardiomyopathies reveal complexities challenging existing dogmas. Biophysical Journal 2023; 122, 4632-4634.
Christopher Marang, Brett Scott, James Chambers, Laura K. Gunther, Christopher M. Yengo, and Edward P. Debold. A mutation in switch I alters the load-dependent kinetics of myosin Va. Nature Communications 2023;14:3137.
Sarah R. Clippinger Schulte, Brent Scott, Samantha K. Barrick, W. Tom Stump, Thomas Blackwell, and Michael J. Greenberg. Single-molecule mechanics and kinetics of cardiac myosin interacting with regulated thin filaments. Biophysical Journal 2023; 122: 2544-2555.
Brent Scott, Christopher Marang, Mike Woodward, and Edward P. Debold. Myosin's powerstroke occurs prior to the release of phosphate from the active site. Cytoskeleton 2021; 1-14.