menu
William and Mary
search
Directory Page Title

Christopher Del Negro

Associate Professor and Chair of Applied Science,

Office : McGlothlin-Street Hall 303
Phone : 757-221-7808
Email : [[cadeln]]

Education
  • 1993 - 1998 Ph.D. in Physiological Sciences, University of California at Los Angeles, California
  • 1988 - 1992 B.A. in Kinesiology/Exercise Science (Magna Cum Laude, with Honors), Occidental College, Los Angeles, California.
Professional Positions
  • 2003 - Present
    Associate Professor, Deparment of Applied Science, The College of William and Mary, Williamsburg, Virginia.
  • 2001 - 2003
    Parker B. Francis Fellow, Department of Neurobiology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California.
  • 1999 - 2001
    Postdoctoral Research Fellow, National Institute of Neurobiological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, Maryland.
Publications
  • Rubin, J. E., Hayes, J. A., Mendenhall, J. L., and Del Negro, C. A. (2009) Calcium-activated nonspecific cation current and synaptic depression promote network-dependent burst oscillations. PNAS, in press.
  • Pace, R. W. and Del Negro, C. A. (2008) AMPA and metabotropic glutamate receptors cooperatively generate inspiratory-like depolarization in mouse respiratory neurons in vitro. European Journal of Neuroscience, 28: 2434-2442.
  • Nesse, W. H., Del Negro, C. A., and Bressloff, P. C. (2008) Oscillation regularity in noise-driven excitable systems with multi-timescale adaptation. Physical Review Letters, 8: 101, 2008
  • Pace, R. W. and Del Negro, C. A. (2008) AMPA and metabotropic glutamate receptors cooperatively generate inspiratory-like depolarization in mouse respiratory neurons in vitro. European Journal of Neuroscience, 28: 2434–2442, 2008
  • Del Negro, C. A., Hayes, J. A., Pace, R. W. (2008) preBötzinger Complex inspiratory neurons and rhythm generation. In Encyclopedia of Neuroscience. London: Elsevier, in press.
  • Feldman, J. L., McCrimmon, D. R., Mitchell, G. S., and Del Negro, C. A. (2008) Generation of respiratory rhythm in mammals. In Encyclopedia of Neuroscience. London: Elsevier, in press.
  • Del Negro, C. A. and Hayes, J. A. (2008) A 'group pacemaker' mechanism for respiratory rhythm generation. Journal of Physiology, 586.9: 2245-6.
  • Hayes, J. A., Mendenhall, J. L., Brush, B. R., and Del Negro, C. A. (2008) 4-aminopyridine-sensitive outward currents in preBötzinger Complex neurons influence respiratory rhythm generation in neonatal mice. Journal of Physiology, 586.7: 1921-36.
  • Del Negro, C. A., Pace, R. W., and Hayes, J. A. (2008) What role do pacemakers play in the generation of respiratory rhythm? In Modeling and Control of Breathing. Integration in Respiratory Control: Genes to Systems. M. J. Poulin and Wilson, R. J. A. editors. New York: Springer Science + Business Media, 88-93.
  • Crowder, E. A., Saha, M. S., Pace, R. W., Zhang, H., Prestwich, G. D., and Del Negro, C. A. (2007) Phosphatidylinositol 4,5-biphosphate regulates inspiratory burst activity in the neonatal mouse preBötzinger complex. Journal of Physiology, 582: 1047-58.
  • Pace, R. W., Mackay, D. D., Feldman, J. L., and Del Negro, C. A. (2007) Inspiratory bursts in the preBötzinger complex depend on a calcium-activated nonspecific cationic current linked to glutamate receptors. Journal of Physiology 582: 113-25.
  • Hayes, J. A. and Del Negro, C. A. (2007) Neurokinin receptor-expressing neurons of the preBötzinger complex and their rhythmogenic electrical properties. Journal of Neurophysiology, 97: 4215-24.
  • Pace, R. W., Mackay, D. D., Feldman, J. L., and Del Negro, C. A. (2007) Role of persistent sodium current in preBötzinger complex neurons and respiratory rhythm generation. Journal of Physiology 580: 485-96.
  • Forster, H. V., Lalley, P. M., Greer, J., Nattie, E. E., Li, A., Del Negro, C. A., Gray, P. A., Dutschmann, M., Rybak, I. A., Dick, T. E., Johnson, S. M., Hedrick, M. S., Funk, G. D., Vasilakos, S. M., Wildon, R. J. A., Ballanyi, K., and Mellen, N. M. (2006) The parafacial respiratory group (pFRG)/pre-Bötzinger complex (preBötC) is the primary site of respiratory rhythm generation in the mammal. Journal of Applied Physiology 100: 2103-2108.
  • Feldman, J. L. and Del Negro, C. A. (2006) Looking for inspiration: new perspectives into the generation of respiratory rhythm. Nature Reviews Neuroscience 7: 232-242.
  • Del Negro, C. A., Morgado-Valle, C., Hayes, J. A., Mackay, D. D., Pace, R. W., Crowder, E. A., and Feldman, J. L. (2005) Sodium and calcium dependent pacemaker neurons and respiratory rhythm generation. Journal of Neuroscience, 25(2): 446-53.
  • Sekerli, R. H., Lee, R. H., Del Negro, C. A., and Butera, R. J. (2004) Estimating action potential thresholds from neuronal time series: new metrics and evaluation of methodologies. IEEE Transactions on Biomedical Engineering, 51(9): 1665-72.
  • Del Negro, C. A., Koshiya, N., Butera, R. J., and Smith, J. C. (2002) Persistent sodium current, membrane properties, and intrinsic bursting behavior of pre-Bötzinger complex inspiratory neurons in vitro. Journal of Neurophysiology, 88(5): 2242-50.
  • Del Negro, C. A., Morgado-Valle, C., and Feldman, J. L. (2002) Respiratory rhythm: an emergent network property? Neuron, 34: 821-30.
  • Del Negro, C. A., Wilson, C. G., Butera, R. J., and Smith, J. C. (2002) Periodicity, mixed-mode oscillations, and quasiperiodicity in a rhythm-generating neural network. Biophysical Journal, 82(1): 206-14.
  • Butera, R. J., Wilson, C. G., Del Negro, C. A., and Smith, J. C. (2001) A methodology for achieving high-speed rates for artificial conductance injection in electrically excitable biological cells. IEEE Transactions on Biomedical Engineering, 48(12): 1460-70.
  • Del Negro, C. A., Butera, R. J., Johnson, S. M., and Smith, J. C. (2001) Models of respiratory rhythm generation in the pre-Bötzinger complex. III. Experimental tests of model predictions. Journal of Neurophysiology, 86(1): 59-74.
  • Wilson, C. G., Butera, R. J., Del Negro, C. A., Rinzel, J., and Smith, J. C. (2001) Interfacing computer models with neurons: respiratory “cyberneurons” created with the dynamic clamp. In Frontiers in Modeling and Control of Breathing: Integration at Molecular, Cellular, and Systems Levels, C.-S. Poon and H. Kazemi, editors. New York: Kluwer, 119-24.
  • Del Negro, C. A., Wilson, C. G., Butera, R. J., Koshiya, N., Johnson, S. M., and Smith, J. C. (2001) Unstable breathing rhythms and quasiperiodicity in the pre-Bötzinger complex. In Frontiers in Modeling and Control of Breathing: Integration at Molecular, Cellular, and Systems Levels, C.-S. Poon and H. Kazemi, editors. New York: Kluwer, 133-8.
  • Smith, J. C., Butera, R. J., Koshiya, N., Del Negro, C. A., Wilson, C. G., and Johnson, S. M. (2000) Respiratory rhythm generation in neonatal and adult mammals: the hybrid pacemaker-network model. Respiration Physiology, 122(2-3): 131-47.
  • Butera, R. J., Johnson, S. M., Del Negro, C. A., Rinzel, J. R. and Smith, J. C. (2000) Dynamics of excitatory networks of pacemaker neurons: experimental and modeling studies of the respiratory rhythm generator. Neurocomputing, 32-33: 323-30.
  • Chandler, S. H., Del Negro, C. A., and Hsiao, C.-F. (1999) Trigeminal motoneurons, interneurons, and the control of neuronal discharge. In Neurobiology of Mastication- From Molecular to Systems Approach, Y. Nakamura and B. J. Sessle, editors. Amsterdam: Elsevier, 99-115.
  • Del Negro, C. A., Hsiao, C.-F., and Chandler, S. H. (1999) Slow outward currents influencing bursting dynamics in guinea pig trigeminal motoneurons. Journal of Neurophysiology, 81(4): 1478-85.
  • Del Negro, C. A. and Chandler, S. H. (1998) Regulation of intrinsic and synaptic properties of neonatal rat trigeminal motoneurons by metabotropic glutamate receptors. Journal of Neuroscience, 18(22): 9216-26.
  • Del Negro, C. A., Hsiao, C.-F., Chandler, S. H., and Garfinkel, A. (1998) Evidence for a novel mechanism of bursting in rodent trigeminal neurons. Biophysical Journal, 75(1): 174-82.
  • Hsiao, C.-F., Del Negro, C. A., Trueblood, P. R., and Chandler, S. H. (1998) Ionic basis for serotonin-induced bistable membrane properties in guinea pig trigeminal motoneurons. Journal of Neurophysiology, 79(6): 2847-56.
  • Del Negro, C. A. and Chandler, S. H. (1997) Physiological and theoretical analysis of K+ currents controlling discharge in neonatal rat mesencephalic trigeminal neurons. Journal of Neurophysiology, 77(2): 537-53.