Previous Scholars' Accomplishments

2011 - 2012
Sam Harvey '12

Research Project: How Helicobacter pylori  (a human gastric pathogen that causes peptic ulcer disease) senses changes in the environment and responds to those changes on a genetic level.

2010 - 11
Frederick Lambert '11

Research Project: Using  safe and inexpensive bismuth catalysts for the synthesis of dihydropyrans - a structural unit commonly found in antibiotics and anti-cancer drugs.

Brittany Lewis '11

Research Project: "My specific project is looking at how calcium ions affect the nervous system and how neurons differentiate and acquire a neurotransmitter phenotype."

2008-09
Michael Harper '09

Research Project: The Role of Notch Signaling in Neurotransmitter Phenotype Specification in Xenopus laevis

2007-08
Andrew Hughes

Research Project: Assessing the Role of Ca2+ Activity in Neurotransmitter Phenotype Determination

Scholarly Recognition: 

  • Honors, senior honors thesis (see title above)
  • First-author poster, national meeting of the Society of Developmental Biology
Ian Webb

Research Project: Gas-Phase Acidities and Proton Affinities of Amino Acid Analogues from the Extended Kinetic Method

Scholarly Recognition:

  • Honors, senior honors thesis (see title above)
  • Research presentations at undergraduate science symposia
  • Coauthor, "Gas-phase acidities of the 20 protein amino acids," International Journal of Mass Spectrometry, 267:1-3 (1 November 2007), 54-62.2006-07
2006-07
Maria Happel

Research Project: Specification of Neurotransmitter Phenotypes in Xenopus laevis

Scholarly Recognition:

  • Highest honors, senior honors thesis (see title above)
  • Guy Prize recipient, W&M Chemistry Department's highest award for graduating seniors
  • Presentation: "Investigations of the Effects of Different Collision-Energy Regimes on Derived Thermochemistry from the Extended Kinetic Method." Maria Happel, Mary Disa M. Raulfs, Jennifer Roskowski, Paul G. Wenthold and John C. Poutsma 55th American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics, Indianapolis, IN, (May 2007).
  • Paper: "Investigations of the Effects of Different Collision-Energy Regimes on Derived Thermochemistry from the Extended Kinetic Method." Maria Happel, Mary Disa M. Raulfs, Jennifer Roskowski, Paul G. Wenthold and John C. Poutsma, to be submitted.
Natasha Golub

Research Project: Specification of neurotransmitter phenotypes in early developmental stages of Xenopus laevis

Presentations:

  • Golub, N.I., Wester, M., Fisher, K.I., Seeley, J., Saha, M.S. "Specification of neurotransmitter phenotypes in Xenopus laevis," Beckman Scholars Symposium, Irvine CA (July 2007).
  • Golub, N.I., Wester, M., Fisher, K.I., Seeley, J., Saha, M.S. "Specification of neurotransmitter phenotypes in Xenopus laevis," Morphogenesis and Regenerative Medicine, Charlottesville, VA (May 2007).
  • Golub, N.I., Fame, R.M., Saha, M.S. "Specification of neurotransmitter phenotypes in Xenopus laevis," Society for Developmental Biology Meeting, Ann Arbor, MI (June 2006).
  • Li, M., Fame, R., Fisher, K., Golub, N., Saha, M. "Specification of the GABAergic and Glutamatergic Phenotype in Xenopus laevis," Morphogenesis and Regenerative Medicine, Charlottesville, VA (May 2005).
2005-06
Katherine Fisher

Research Project: Determination of the Default Vertebrate Neural Phenotype in Early Development

2004-05
Melissa Sprachman

Research Project: The Use of Bismuth Compounds in the Non-toxic Syntheses of Natural Products

Scholarly Presentations:

  • "Stereoselective Tandem Cylization-Addition Reactions Using Catalytic BiBr3," Southeastern Regional Meeting of the American Chemical Society (SERMACS), November 2004, Research Triangle Park, NC (poster presentation).
  • "Bismuth Initiated Tandem Cyclization-Addition Reactions for the Synthesis of Cyclic Ethers," Beckman Scholars Symposium, July 2005, Irvine, CA (poster presentation).
  • "Selective Tandem Cyclization-Addition Reactions Using Catalytic Quantities of BiBr3 and pi-Nucleophiles," 230th National Meeting of the American Chemical Society, August-September 2005, Washington, D.C. (poster presentation).
Lamia Wahba

Research Project: Chromosome Mutation 528 in C. elegans

Scholarly Presentations:

  • "Chromosome mutation 528 in C. elegans: Who, What and When?" Undergraduate Science Research Symposium, College of William and Mary, September 2004, Williamsburg, VA.
  • "Chromosome segregation defect 528 in C. elegans (and modeling the cell cycle)" Beckman Scholars Symposium, July 2005, Irvine, CA.
  • "Chromosome segregation defects in Caenorhabditis elegans," Undergraduate Symposium, September 2005, Richmond, VA (poster presentation).
  • "Modeling the cell cycle in C. elegans, and chromosome segregation defects," Cell Biology meeting, December 2005, San Francisco, CA (poster presentation).
2003-04
Vijay Dondeti

Research Project: Using Microarrays to Study Neural Differentiation and Plasticity in Xenopus laevis

Publications:

  • V. R. Dondeti, M. A. Wright, and M. S. Saha, "Design of an 8K Xenopus Microarray for Investigating Neural Development," Developmental Biology, 2003, 259(2): 527.
  •  V. R. Dondeti, C. W. Sipe, and M. S. Saha, "A Gene Selection Strategy for Custom Microarray Design," Biotechniques, 2004, 37(5):768-70, 772, 774-6.

Scholarly Presentations:

  • "A Gene Selection Strategy for Custom Microarray Design: Application to a Xenopus Microarray," Sixth Annual Beckman Scholars Symposium, July 2004, Irvine, CA.
  • "Molecular Analysis of Early Embryonic Plasticity in CNS," Morphogenesis and Regenerative Medicine Symposium, May 2003, Charlottesville, VA (poster presentation).
  • "Design of an 8K Xenopus Microarray for Investigating Neural Development," Society for Developmental Biology Meeting, July 2003, Boston, MA (poster presentation).
Megan Dellinger

Research Project: Design, Synthesis and Catalysis Application of Metal Network Materials

Publications:

  • J. R. Cole, M. E. Dellinger, T. J. Johnson, B. A. Reinecke, R. D. Pike, W. T. Pennington, M. Krawiec and A. L. Rheingold, "Caged Phosphite Complexes of Copper(I) Halides," Journal of Chemical Crystallography, 2003, 33, 341-347.
  • R. D. Pike, B. A. Reinecke, M. E. Dellinger, A. B. Wiles, J. D. Harper, J. R. Cole, K. A. Dendramis, B. D. Borne, J. L. Harris, and W. T. Pennington, "Bicyclic Phosphite Esters from Pentaerythritol and Dipentaerythritol: New Bridging Ligands in Organometallic and Inorganic Chemistry," Organometallics, 2004, 23, 1986-1990.

Scholarly Presentations:

  • B. D. Borne, J. R. Cole, M. E. Dellinger, K. A. Dendramis, J. D. Harper, and R. D. Pike, "Caged Phosphite Ligands from Pentaerythritol and Dipentaerythritol," 54th Southeastern Regional Meeting of the American Chemical Society, November 2002, Charleston, SC.
  • R. D. Pike, M. E. Dellinger, B. A. Reinecke, A. B. Wiles, "New Caged Phosphite Metal-Organic Networks," 55th Southeastern Regional Meeting of the American Chemical Society, November 2003, Atlanta, GA.
2001-02
Edith Bowers

Research Project: Development of New Techniques for Studying Protein Structure and Folding

Publications:

  • Bebout, D. C.; Bush, J. F., II; Crahan, K. K.; Bowers, E. V.; Butcher, R. J. "Sterically Demanding Multidentate Ligand Tris[2-(6-methylpyridyl)methyl]amine Slows Exchange and Enhances Solution State Ligand Proton NMR Coupling to 199Hg(II)" Inorg. Chem 2002, 41, 2529.
  • Bebout, D. C.; Murphy, G. S.; Garland, M. M.; Bowers, E. V.; Butcher, R. J. "Investigation of the Mercury(II) Coordination Chemistry of Tris[(1-methylimidazol-2-yl)methyl]amine by X-ray Crystallography and NMR," Dalton Trans. 2003, 2578-2584.

Scholarly Presentations:

  • Bowers, E.V.; Monsess, R. L.; Garland, M. M.; Bebout, D. C.; Butcher, R. J. "Effects of Ligand Symmetry on Hg(II) Coordination" presented at the 220th ACS National Meeting, Washington, D.C., August 21, 2000, CHED 173.
  • Bowers, E. V.; Monsess, R. L.; Garland, M.M.; Bebout, D. C.; Butcher, R. J. "Effects of Ligand Symmetry on Hg(II) Coordination" presented at the Virginia Section ACS Meeting, Richmond, VA, September 29, 2000.
  • Bowers, E. V.; Bebout, D. C. "Development of New Techniques for Studying Protein Structure and Folding" Fourth Annual Beckman Scholars Symposium, Newport News, CA, July 2002.
  • Bowers, E. V.; Bebout, D. C.; Stokes, S. W.; Clements, J. C.; Kastner, M. E.; Butcher, R. J. "Comparison of Hg(II) and Cd(II) coordination with dipodal and tripodal ligand systems" 224th ACS National Meeting, Boston, MA, August 2002, CHED 159.
Christen Raymond

Research Project: Variation in the Neuroendicrine Pathway of Reproductive Photoresponsiveness in Rodents

Scholarly Presentations:

  • Raymond, Christen M.; Kristin A. Schubert, and Paul D. Heideman. Variation in Sensitivity to Steroid Negative Feedback in a Population of White-footed Mice, Peromyscus leucopus. Eighth meeting of the Society for Research on Biological Rhythms, Amelia Island Plantation, Jacksonville, Florida, 22-26 May, 2002 (Poster Presentation).
  • Raymond, Christen M.; Kristin A. Schubert, and Paul D. Heideman. Variation in the Neuroendocrine Pathway of Reproductive Photoresponsiveness in Rodents. Fourth Annual Beckman Scholar Symposium, Arnold and Mabel Beckman Center of the National Academies of Sciences and Engineering, Irvine, CA. 25-27 July, 2002. (Poster Presentation)
2000-01
Annaka Begley Lorincz

Research Project: Neural Variation Using Photperiod as a Model

Publications:

  • Price, Matthew R. Kruse, Julie A. M., Galvez, Eric, Lorincz, Annaka M., Avigdor, Mauricio and Heideman, Paul D. 2005. Failure to Respond to Endogenous or Exogenous Melatonin May Cause Nonphotoresponsiveness in Harlan Sprague Dawley Rats. Journal of Circadian Rhythms 3:12
  • Lorincz, Annaka M., M. Benjamin Shoemaker, and Paul D. Heideman. "Genetic variation in photoperiodism among naturally photoperiodic rat strains," American Journal of Physiology: Regulatory, Integrative and Comparative Physiology (revised manuscript in review).

Scholarly Presentations:

  • Verizon Undergraduate Research Symposium, September, 2001.
  • "Brain Variation Using Photoperiod as a Model," Third Annual Beckman Scholar Symposium, Irvine, CA. (July, 2001).
Ann Mikowski

Research Project: Aryl Iodanes: Syntheses and Reactivity

Publications:

  • Hinkle, R. J., Mikowski, A. M. "Kinetics of Stereoisomeric 2-Methyl-1-butenyl-(aryl)iodonium triflates," Included in a special issue of ARKIVOC 2003, vi, 201-212, published 25 July 2003: http://www.arkat-usa.org/ark/journal/2003/Varvoglis/AV-

Scholarly Presentations:

  • Mikowski, A. M., Hinkle, R. J., "The Attempted Synthesis of Alkenylbenziodoxole Derivatives," Verizon Undergraduate Science Research Symposium, 15 September 2000; poster 52.
  • Mikowski, A. M., Hinkle, R. J., "Aryl Iodanes: Syntheses and Reactivity," Third Annual Beckman Scholar Symposium, Irvine, CA. (July 2001).
  • Mikowski, A. M., Hinkle, R. J. "Fragmentation Reactions of Alkenyl(aryl)iodonium Salts," Verizon Undergraduate Research Symposium at William and Mary, September. 2001. Poster Presentation.
  • Hinkle, R. J., Mikowski, A. M. "Fragmentation Reactions of Alkenyl(aryl)iodonium Tiflates Salts." Presented at the 223rd American Chemical Society Meeting, Orlando, Fl, April 06-11, 2002. Poster Presentation 332.
1998-99
Kristina Hoke

Research Project: Role of Neurotransmitter Systems in Embryonic Brain Development

Scholarly Presentations:

  • Undergraduate Research Symposium, College of William and Mary, September, 1999.
  • First Annual Arnold and Mabel Beckman Scholar Symposium, Irvine, CA (July 22-24, 1999).
  • National Symposium for the Society of Developmental Biology, June, 1999 (poster presentation). Abstract published in Developmental Biology, Society for Developmental Biology Program/ Abstracts, Academic Press (June, 1999).
Anne McNeil

Research Project: Synthesis and Solvolysis of Alkenyl(arl)iodonium Triflates.

Publications:

  • McNeil, A. J.; Hinkle, R. J.; Rouse, E. A.; Thomas, Q. A.; Thomas, D. B. "Vinyl Carbocations: Solution Studies of Alkenyl(aryl)iodonium Triflate Fragmentations," Journal of Organic Chemistry, 2001, 66, 5556-5565.
  • Hinkle, R. J., McNeil, A. J., Thomas, Q. A., Andrews, M. N., "Vinyl Cations in Solution: Kinetics and Products of Alkenyl(arl)iodonium Salt Fragmentations," Journal of the American Chemical Society, 1999, 121, 7437-7438.

Scholarly Presentations:

  • McNeil, A.J., Hinkle, R. J., "Synthesis and Solvolysis of Alkenyl(arl)iodonium Triflates," First Annual Arnold and Mabel Beckman Scholar Symposium, Irvine, CA (July 22-24, 1999).
  • McNeil, A. J., Thomas, Q. B., Andrews, M. N. (Hinkle, R. J.), Thirteenth National Conference on Undergraduate Research, University of Rochester, Rochester, NY (April 8-10, 1999).
  • Hinkle, R. J., Aubry, Q. D., McNeil, A.J., National American Chemical Society Meeting, Boston, MA (August 23-27, 1998), poster 240.
Lucia Wille

Research Project: The Anaphase-Promoting Complex is Required for C. elegans Meiosis I Anaphase

Publications:

  • *Davis ES, *Wille L, Chestnut B, Sadler P, Shakes D, and Golden A. (2002) Multiple subunits of the C. elegans Anaphase Promoting Complex are required for chromosome segregation during meiosis I. Genetics 160: 805-813. (*co-first authors)
  • Sadler, P, Wille L, Young T, Holt G, Johnson N, Letts D, Kaattari I, Thomas J, and Shakes D, "MAT mutants: Metaphase-anaphase transition Defective," Worm Breeder's Gazette 15, no. 4 (1998): 44.
  • Chase D, Wille L, Ferris D, Golden A, and Shakes D, "Chromosome segregation: A role for APC genes in C. elegans," Worm Breeder's Gazette,15, no. 4, (1998): 45.

Scholarly Presentations:

  • Wille, L and Shakes, D.C, "The anaphase-promoting complex is required for C. elegans meiosis I anaphase," William and Mary Undergraduate Science Research Symposium. September 1999.
  • Wille, L and Shakes, D.C, "The anaphase-promoting complex is required for C. elegans meiosis I anaphase," The First Annual Beckman Scholars Symposium, Irvine, CA, July 1999.
  • Wille, L. and Shakes, D. C., "Mitotic defects in C. elegans emb-27 mutants," William and Mary Undergraduate Science Research Symposium. September 1998.
  • Wille L, Abdolrasulnia M, and Shakes, D, "The anaphase-promoting complex is required for meiosis I anaphase," International C. elegans Conference. Madison, WI. June 2-7, 1998.